The Advanced SpaceLife Research Institute's Sexual Health and Reproductive Planning (SHARP) Mission Roadmap for Multigenerational Human Space Settlement is a comprehensive, multi-stage research plan designed to address 8 Major Areas of Concern (MACs) pertaining to human reproduction, sexual health, behavior, and function in space environments over the next 30 years. SHARP incorporates 200+ projected research missions -- both analog and orbital -- and 30+ Earth-based summit events.  Findings from these will fill key knowledge gaps to enable humanity's expansion into and permanent settlement of space environments -- from cislunar, to Mars, to the outer reaches of our solar system and beyond.